Publications

Found 22 results
Filters: Author is B I Fedeles  [Clear All Filters]
2023
Armijo AL, Thongararm P, Fedeles BI, Yau J, Kay JE, Corrigan JJ, Chancharoen M, Chawanthayatham S, Samson LD, Carrasco SE, et al. Molecular origins of mutational spectra produced by the environmental carcinogen N-nitrosodimethylamine and SN1 chemotherapeutic agents. NAR Cancer. 2023 ;5(2):zcad015.
2022
Aralov AV, Gubina N, Cabrero C, Tsvetkov VB, Turaev AV, Fedeles BI, Croy RG, Isaakova EA, Melnik D, Dukova S, et al. 7,8-Dihydro-8-oxo-1,N6-ethenoadenine: an exclusively Hoogsteen-paired thymine mimic in DNA that induces A→T transversions in Escherichia coli. Nucleic Acids Res. 2022 ;50(6):3056-3069.
Jimenez-Macias JL, Lee Y-C, Miller E, Finkelberg T, Zdioruk M, Berger G, Farquhar CE, Nowicki MO, Cho C-F, Fedeles BI, et al. A Pt(IV)-conjugated brain penetrant macrocyclic peptide shows pre-clinical efficacy in glioblastoma. J Control Release. 2022 ;352:623-636.
Fedeles BI, Li D, Singh V. Structural Insights Into Tautomeric Dynamics in Nucleic Acids and in Antiviral Nucleoside Analogs. Front Mol Biosci. 2022 ;8:823253.
2021
Tajai P, Suriyo T, Rangkadilok N, Fedeles BI, Essigmann JM, Satayavivad J. Andrographolide, an Antioxidant, Counteracts Paraquat-Induced Mutagenesis in Mammalian Cells. Asian Pac J Cancer Prev. 2021 ;22(S1):3-8.
2020
Thongararm P, Fedeles BI, Khumsubdee S, Armijo AL, Kim L, Thiantanawat A, Promvijit J, Navasumrit P, Ruchirawat M, Croy RG, et al. Modulation of N-Methyl-N-nitrosourea Mutagenesis in Mouse Embryo Fibroblasts Derived from the Delta-gpt Mouse by an Inhibitor of the O6-Methylguanine Methyltransferase, MGMT. Chem Res Toxicol. 2020 ;33(2):625-633.
Fedeles BI, Essigmann JM. Mutational spectra provide insight into the mechanisms bridging DNA damage to genetic disease. In: DNA Damage, DNA Repair and Disease. Vol. 2. DNA Damage, DNA Repair and Disease. London, UK: Royal Society of Chemistry; 2020. pp. 214-253.
2018
Tajai P, Fedeles BI, Suriyo T, Kanitwithayanun J, Essigmann JM, Satayavivad J. An engineered cell line lacking OGG1 and MUTYH glycosylases implicates the accumulation of genomic 8-oxoguanine as the basis for paraquat mutagenicity. Free Radical Biology and Medicine [Internet]. 2018 ;116. Available from: https://www.sciencedirect.com/science/article/pii/S089158491731287X
Fedeles BI, Essigmann JM. Impact of DNA lesion repair, replication and formation on the mutational spectra of environmental carcinogens: Aflatoxin B as a case study. DNA Repair (Amst). 2018 ;71:12-22.
2017
Fedeles BI, Chawanthayatham S, Croy RG, Wogan GN, Essigmann JM. Early detection of the aflatoxin B1 mutational fingerprint: A diagnostic tool for liver cancer. Molecular & Cellular Oncology. 2017 ;4(4).
Chawanthayatham S, Valentine CC, Fedeles BI, Fox EJ, Loeb LA, Levine SS, Slocum SL, Wogan GN, Croy RG, Essigmann JM. Mutational spectra of aflatoxin B1 in vivo establish biomarkers of exposure for human hepatocellular carcinoma. PNAS [Internet]. 2017 ;114(15):E3101-E3109. Available from: http://www.pnas.org/content/early/2017/03/27/1700759114?tab=ds
Chen F, Bian K, Tang Q, Fedeles BI, Singh V, Humulock ZT, Essigmann JM, Li D. Oncometabolites d- and l-2-Hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions. Chem Res Toxicol. 2017 ;30(4):1102-1110.
Sriwattanapong K, Slocum SL, Chawanthayatham S, Fedeles BI, Egner PA, Groopman JD, Satayavivad J, Croy RG, Essigmann JM. Pregnancy Alters Aflatoxin B1 Metabolism and Increases DNA Damage in Mouse Liver. Toxicol Sci. 2017 ;160(1):173-179.
2015
Fedeles BI, Singh V, Delaney JC, Li D, Essigmann JM. The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond. J Biol Chem. 2015 ;290(34):20734-42.
Fedeles BI, Freudenthal BD, Yau E, Singh V, Chang S-C, Li D, Delaney JC, Wilson SH, Essigmann JM. Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer. Proc Natl Acad Sci U S A. 2015 ;112(33):E4571-80.
Chang S-C, Fedeles BI, Wu J, Delaney JC, Li D, Zhao L, Christov PP, Yau E, Singh V, Jost M, et al. Next-generation sequencing reveals the biological significance of the N(2),3-ethenoguanine lesion in vivo. Nucleic Acids Res. 2015 ;43(11):5489-500.
Singh V, Fedeles BI, Essigmann JM. Role of tautomerism in RNA biochemistry. RNA. 2015 ;21(1):1-13.
2014
Shrivastav N, Fedeles BI, Li D, Delaney JC, Frick LE, Foti JJ, Walker GC, Essigmann JM. A chemical genetics analysis of the roles of bypass polymerase DinB and DNA repair protein AlkB in processing N2-alkylguanine lesions in vivo. PLoS One. 2014 ;9(4):e94716.
Singh V, Fedeles BI, Li D, Delaney JC, Kozekov ID, Kozekova A, Marnett LJ, Rizzo CJ, Essigmann JM. Mechanism of Repair of Acrolein- and Malondialdehyde-Derived Exocyclic Guanine Adducts by the α-Ketoglutarate/Fe(II) Dioxygenase AlkB. Chem Res Toxicol. 2014 ;27(9):1619-31.
Li D, Fedeles BI, Singh V, Peng CSam, Silvestre KJ, Simi AK, Simpson JH, Tokmakoff A, Essigmann JM. Tautomerism provides a molecular explanation for the mutagenic properties of the anti-HIV nucleoside 5-aza-5,6-dihydro-2'-deoxycytidine. Proc Natl Acad Sci U S A. 2014 ;111(32):E3252-9.
2013
Li D, Fedeles BI, Shrivastav N, Delaney JC, Yang X, Wong C, Drennan CL, Essigmann JM. Removal of N-alkyl modifications from N(2)-alkylguanine and N(4)-alkylcytosine in DNA by the adaptive response protein AlkB. Chem Res Toxicol. 2013 ;26(8):1182-7.
2011
Fedeles BI, Zhu AY, Young KS, Hillier SM, Proffitt KD, Essigmann JM, Croy RG. Chemical genetics analysis of an aniline mustard anticancer agent reveals complex I of the electron transport chain as a target. J Biol Chem. 2011 ;286(39):33910-20.