Publications
Found 22 results
Filters: Author is B I Fedeles [Clear All Filters]
7,8-Dihydro-8-oxo-1,N6-ethenoadenine: an exclusively Hoogsteen-paired thymine mimic in DNA that induces A→T transversions in Escherichia coli. Nucleic Acids Res. 2022 ;50(6):3056-3069.
A Pt(IV)-conjugated brain penetrant macrocyclic peptide shows pre-clinical efficacy in glioblastoma. J Control Release. 2022 ;352:623-636.
Structural Insights Into Tautomeric Dynamics in Nucleic Acids and in Antiviral Nucleoside Analogs. Front Mol Biosci. 2022 ;8:823253.
. Andrographolide, an Antioxidant, Counteracts Paraquat-Induced Mutagenesis in Mammalian Cells. Asian Pac J Cancer Prev. 2021 ;22(S1):3-8.
. Modulation of N-Methyl-N-nitrosourea Mutagenesis in Mouse Embryo Fibroblasts Derived from the Delta-gpt Mouse by an Inhibitor of the O6-Methylguanine Methyltransferase, MGMT. Chem Res Toxicol. 2020 ;33(2):625-633.
Mutational spectra provide insight into the mechanisms bridging DNA damage to genetic disease. In: DNA Damage, DNA Repair and Disease. Vol. 2. DNA Damage, DNA Repair and Disease. London, UK: Royal Society of Chemistry; 2020. pp. 214-253.
. An engineered cell line lacking OGG1 and MUTYH glycosylases implicates the accumulation of genomic 8-oxoguanine as the basis for paraquat mutagenicity. Free Radical Biology and Medicine [Internet]. 2018 ;116. Available from: https://www.sciencedirect.com/science/article/pii/S089158491731287X
. Impact of DNA lesion repair, replication and formation on the mutational spectra of environmental carcinogens: Aflatoxin B as a case study. DNA Repair (Amst). 2018 ;71:12-22.
. Early detection of the aflatoxin B1 mutational fingerprint: A diagnostic tool for liver cancer. Molecular & Cellular Oncology. 2017 ;4(4).
. Mutational spectra of aflatoxin B1 in vivo establish biomarkers of exposure for human hepatocellular carcinoma. PNAS [Internet]. 2017 ;114(15):E3101-E3109. Available from: http://www.pnas.org/content/early/2017/03/27/1700759114?tab=ds
. Oncometabolites d- and l-2-Hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions. Chem Res Toxicol. 2017 ;30(4):1102-1110.
. Pregnancy Alters Aflatoxin B1 Metabolism and Increases DNA Damage in Mouse Liver. Toxicol Sci. 2017 ;160(1):173-179.
. The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond. J Biol Chem. 2015 ;290(34):20734-42.
. Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer. Proc Natl Acad Sci U S A. 2015 ;112(33):E4571-80.
. Next-generation sequencing reveals the biological significance of the N(2),3-ethenoguanine lesion in vivo. Nucleic Acids Res. 2015 ;43(11):5489-500.
Role of tautomerism in RNA biochemistry. RNA. 2015 ;21(1):1-13.
. A chemical genetics analysis of the roles of bypass polymerase DinB and DNA repair protein AlkB in processing N2-alkylguanine lesions in vivo. PLoS One. 2014 ;9(4):e94716.
. Mechanism of Repair of Acrolein- and Malondialdehyde-Derived Exocyclic Guanine Adducts by the α-Ketoglutarate/Fe(II) Dioxygenase AlkB. Chem Res Toxicol. 2014 ;27(9):1619-31.
. Tautomerism provides a molecular explanation for the mutagenic properties of the anti-HIV nucleoside 5-aza-5,6-dihydro-2'-deoxycytidine. Proc Natl Acad Sci U S A. 2014 ;111(32):E3252-9.
. Removal of N-alkyl modifications from N(2)-alkylguanine and N(4)-alkylcytosine in DNA by the adaptive response protein AlkB. Chem Res Toxicol. 2013 ;26(8):1182-7.
. Chemical genetics analysis of an aniline mustard anticancer agent reveals complex I of the electron transport chain as a target. J Biol Chem. 2011 ;286(39):33910-20.
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