Publications

Found 48 results
Filters: Author is Essigmann, John M  [Clear All Filters]
2023
Feng H, Luo S-XLennon, Croy RG, Essigmann JM, Swager TM. Interaction of N-nitrosamines with binuclear copper complexes for luminescent detection. Dalton Trans. 2023 ;52(10):3219-3233.
Armijo AL, Thongararm P, Fedeles BI, Yau J, Kay JE, Corrigan JJ, Chancharoen M, Chawanthayatham S, Samson LD, Carrasco SE, et al. Molecular origins of mutational spectra produced by the environmental carcinogen N-nitrosodimethylamine and SN1 chemotherapeutic agents. NAR Cancer. 2023 ;5(2):zcad015.
2022
Aralov AV, Gubina N, Cabrero C, Tsvetkov VB, Turaev AV, Fedeles BI, Croy RG, Isaakova EA, Melnik D, Dukova S, et al. 7,8-Dihydro-8-oxo-1,N6-ethenoadenine: an exclusively Hoogsteen-paired thymine mimic in DNA that induces A→T transversions in Escherichia coli. Nucleic Acids Res. 2022 ;50(6):3056-3069.
Basu AK, Essigmann JM. Establishing Linkages Among DNA Damage, Mutagenesis, and Genetic Diseases. Chem Res Toxicol. 2022 ;35(10):1655-1675.
2021
Tajai P, Suriyo T, Rangkadilok N, Fedeles BI, Essigmann JM, Satayavivad J. Andrographolide, an Antioxidant, Counteracts Paraquat-Induced Mutagenesis in Mammalian Cells. Asian Pac J Cancer Prev. 2021 ;22(S1):3-8.
Lu R-Q, Yuan W, Croy RG, Essigmann JM, Swager TM. Metallocalix[4]arene Polymers for Gravimetric Detection of Nitrosodialkylamines. J Am Chem Soc. 2021 ;143(47):19809-19815.
2020
Thongararm P, Fedeles BI, Khumsubdee S, Armijo AL, Kim L, Thiantanawat A, Promvijit J, Navasumrit P, Ruchirawat M, Croy RG, et al. Modulation of N-Methyl-N-nitrosourea Mutagenesis in Mouse Embryo Fibroblasts Derived from the Delta-gpt Mouse by an Inhibitor of the O6-Methylguanine Methyltransferase, MGMT. Chem Res Toxicol. 2020 ;33(2):625-633.
Fedeles BI, Essigmann JM. Mutational spectra provide insight into the mechanisms bridging DNA damage to genetic disease. In: DNA Damage, DNA Repair and Disease. Vol. 2. DNA Damage, DNA Repair and Disease. London, UK: Royal Society of Chemistry; 2020. pp. 214-253.
2019
He M, Croy RG, Essigmann JM, Swager TM. Chemiresistive Carbon Nanotube Sensors for N-Nitrosodialkylamines. ACS Sens. 2019 ;4(10):2819-2824.
Ge Z, Feng Y, Sheh A, Muthupalani S, Gong G, Chawanthayatham S, Essigmann JM, Fox JG. Mutagenicity of Helicobacter hepaticus infection in the lower bowel mucosa of 129/SvEv Rag2 Il10 gpt delta mice is influenced by sex. Int J Cancer. 2019 ;145(4):1042-1054.
2018
Tajai P, Fedeles BI, Suriyo T, Kanitwithayanun J, Essigmann JM, Satayavivad J. An engineered cell line lacking OGG1 and MUTYH glycosylases implicates the accumulation of genomic 8-oxoguanine as the basis for paraquat mutagenicity. Free Radical Biology and Medicine [Internet]. 2018 ;116. Available from: https://www.sciencedirect.com/science/article/pii/S089158491731287X
Fedeles BI, Essigmann JM. Impact of DNA lesion repair, replication and formation on the mutational spectra of environmental carcinogens: Aflatoxin B as a case study. DNA Repair (Amst). 2018 ;71:12-22.
2017
Chang S-C, Seneviratne UI, Wu J, Tretyakova N, Essigmann JM. 1,3-Butadiene-Induced Adenine DNA Adducts Are Genotoxic but Only Weakly Mutagenic When Replicated in Escherichia coli of Various Repair and Replication Backgrounds. Chem Res Toxicol. 2017 ;30(5):1230-1239.
Fedeles BI, Chawanthayatham S, Croy RG, Wogan GN, Essigmann JM. Early detection of the aflatoxin B1 mutational fingerprint: A diagnostic tool for liver cancer. Molecular & Cellular Oncology. 2017 ;4(4).
Chawanthayatham S, Valentine CC, Fedeles BI, Fox EJ, Loeb LA, Levine SS, Slocum SL, Wogan GN, Croy RG, Essigmann JM. Mutational spectra of aflatoxin B1 in vivo establish biomarkers of exposure for human hepatocellular carcinoma. PNAS [Internet]. 2017 ;114(15):E3101-E3109. Available from: http://www.pnas.org/content/early/2017/03/27/1700759114?tab=ds
Vartanian V, Minko IG, Chawanthayatham S, Egner PA, Lin Y-C, Earley LF, Makar R, Eng JR, Camp MT, Li L, et al. NEIL1 protects against aflatoxin-induced hepatocellular carcinoma in mice. Proc Natl Acad Sci U S A. 2017 ;114(16):4207-4212.
Chen F, Bian K, Tang Q, Fedeles BI, Singh V, Humulock ZT, Essigmann JM, Li D. Oncometabolites d- and l-2-Hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions. Chem Res Toxicol. 2017 ;30(4):1102-1110.
Sriwattanapong K, Slocum SL, Chawanthayatham S, Fedeles BI, Egner PA, Groopman JD, Satayavivad J, Croy RG, Essigmann JM. Pregnancy Alters Aflatoxin B1 Metabolism and Increases DNA Damage in Mouse Liver. Toxicol Sci. 2017 ;160(1):173-179.
2016
Chen F, Tang Q, Bian K, Humulock ZT, Yang X, Jost M, Drennan CL, Essigmann JM, Li D. Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA. Chem Res Toxicol. 2016 ;29(4):687-93.
2015
Fedeles BI, Singh V, Delaney JC, Li D, Essigmann JM. The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond. J Biol Chem. 2015 ;290(34):20734-42.
Fedeles BI, Freudenthal BD, Yau E, Singh V, Chang S-C, Li D, Delaney JC, Wilson SH, Essigmann JM. Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer. Proc Natl Acad Sci U S A. 2015 ;112(33):E4571-80.
Chang S-C, Fedeles BI, Wu J, Delaney JC, Li D, Zhao L, Christov PP, Yau E, Singh V, Jost M, et al. Next-generation sequencing reveals the biological significance of the N(2),3-ethenoguanine lesion in vivo. Nucleic Acids Res. 2015 ;43(11):5489-500.
Singh V, Fedeles BI, Essigmann JM. Role of tautomerism in RNA biochemistry. RNA. 2015 ;21(1):1-13.
Techapiesancharoenkij N, Fiala JLA, Navasumrit P, Croy RG, Wogan GN, Groopman JD, Ruchirawat M, Essigmann JM. Sulforaphane, a cancer chemopreventive agent, induces pathways associated with membrane biosynthesis in response to tissue damage by aflatoxin B1. Toxicol Appl Pharmacol. 2015 ;282(1):52-60.
2014
Shrivastav N, Fedeles BI, Li D, Delaney JC, Frick LE, Foti JJ, Walker GC, Essigmann JM. A chemical genetics analysis of the roles of bypass polymerase DinB and DNA repair protein AlkB in processing N2-alkylguanine lesions in vivo. PLoS One. 2014 ;9(4):e94716.
Singh V, Peng CSam, Li D, Mitra K, Silvestre KJ, Tokmakoff A, Essigmann JM. Direct Observation of Multiple Tautomers of Oxythiamine and their Recognition by the Thiamine Pyrophosphate Riboswitch. ACS Chem Biol [Internet]. 2014 ;9(1):227-36. Available from: http://pubs.acs.org/doi/abs/10.1021/cb400581f
Singh V, Fedeles BI, Li D, Delaney JC, Kozekov ID, Kozekova A, Marnett LJ, Rizzo CJ, Essigmann JM. Mechanism of Repair of Acrolein- and Malondialdehyde-Derived Exocyclic Guanine Adducts by the α-Ketoglutarate/Fe(II) Dioxygenase AlkB. Chem Res Toxicol. 2014 ;27(9):1619-31.
Chawanthayatham S, Thiantanawat A, Egner PA, Groopman JD, Wogan GN, Croy RG, Essigmann JM. Prenatal exposure of mice to the human liver carcinogen aflatoxin B1 reveals a critical window of susceptibility to genetic change. Int J Cancer. 2014 .
Li D, Fedeles BI, Singh V, Peng CSam, Silvestre KJ, Simi AK, Simpson JH, Tokmakoff A, Essigmann JM. Tautomerism provides a molecular explanation for the mutagenic properties of the anti-HIV nucleoside 5-aza-5,6-dihydro-2'-deoxycytidine. Proc Natl Acad Sci U S A. 2014 ;111(32):E3252-9.
2013
Zhang J, Landry MP, Barone PW, Kim J-H, Lin S, Ulissi ZW, Lin D, Mu B, Boghossian AA, Hilmer AJ, et al. Molecular recognition using corona phase complexes made of synthetic polymers adsorbed on carbon nanotubes. Nat Nanotechnol. 2013 ;8(12):959-68.
Li D, Fedeles BI, Shrivastav N, Delaney JC, Yang X, Wong C, Drennan CL, Essigmann JM. Removal of N-alkyl modifications from N(2)-alkylguanine and N(4)-alkylcytosine in DNA by the adaptive response protein AlkB. Chem Res Toxicol. 2013 ;26(8):1182-7.
2012
Wattanawaraporn R, Kim MYoung, Adams J, Trudel LJ, Woo LL, Croy RG, Essigmann JM, Wogan GN. AFB(1) -induced mutagenesis of the gpt gene in AS52 cells. Environ Mol Mutagen. 2012 ;53(7):567-73.
Hanson RN, Hua E, Labaree D, Hochberg RB, Proffitt K, Essigmann JM, Croy RG. Convergent synthesis of a steroidal antiestrogen-mitomycin C hybrid using "click" chemistry. Org Biomol Chem. 2012 ;10(42):8501-8.
Li D, Delaney JC, Page CM, Yang X, Chen AS, Wong C, Drennan CL, Essigmann JM. Exocyclic carbons adjacent to the N6 of adenine are targets for oxidation by the Escherichia coli adaptive response protein AlkB. J Am Chem Soc. 2012 ;134(21):8896-901.
Wattanawaraporn R, Woo LL, Belanger C, Chang S-C, Adams JE, Trudel LJ, Bouhenguel JT, Egner PA, Groopman JD, Croy RG, et al. A single neonatal exposure to aflatoxin b1 induces prolonged genetic damage in two loci of mouse liver. Toxicol Sci. 2012 ;128(2):326-33.
2011
Woo LL, Egner PA, Belanger CL, Wattanawaraporn R, Trudel LJ, Croy RG, Groopman JD, Essigmann JM, Wogan GN, Bouhenguel JT. Aflatoxin B1-DNA adduct formation and mutagenicity in livers of neonatal male and female B6C3F1 mice. Toxicol Sci. 2011 ;122(1):38-44.
Fedeles BI, Zhu AY, Young KS, Hillier SM, Proffitt KD, Essigmann JM, Croy RG. Chemical genetics analysis of an aniline mustard anticancer agent reveals complex I of the electron transport chain as a target. J Biol Chem. 2011 ;286(39):33910-20.
Rechkoblit O, Delaney JC, Essigmann JM, Patel DJ. Implications for damage recognition during Dpo4-mediated mutagenic bypass of m1G and m3C lesions. Structure. 2011 ;19(6):821-32.
Fiala JLA, Egner PA, Wiriyachan N, Ruchirawat M, Kensler KH, Wogan GN, Groopman JD, Croy RG, Essigmann JM. Sulforaphane-mediated reduction of aflatoxin B₁-N⁷-guanine in rat liver DNA: impacts of strain and sex. Toxicol Sci. 2011 ;121(1):57-62.
2009
Jarosz DF, Cohen SE, Delaney JC, Essigmann JM, Walker GC. A DinB variant reveals diverse physiological consequences of incomplete TLS extension by a Y-family DNA polymerase. Proc Natl Acad Sci U S A. 2009 ;106(50):21137-42.
2007
Frick LE, Delaney JC, Wong C, Drennan CL, Essigmann JM. Alleviation of 1,N6-ethanoadenine genotoxicity by the Escherichia coli adaptive response protein AlkB. Proc Natl Acad Sci U S A. 2007 ;104(3):755-60.
2006
Delaney JC, Essigmann JM. Assays for determining lesion bypass efficiency and mutagenicity of site-specific DNA lesions in vivo. Methods Enzymol. 2006 ;408:1-15.
Jarosz DF, Godoy VG, Delaney JC, Essigmann JM, Walker GC. A single amino acid governs enhanced activity of DinB DNA polymerases on damaged templates. Nature. 2006 ;439(7073):225-8.
2005
Delaney JC, Smeester L, Wong C, Frick LE, Taghizadeh K, Wishnok JS, Drennan CL, Samson LD, Essigmann JM. AlkB reverses etheno DNA lesions caused by lipid oxidation in vitro and in vivo. Nat Struct Mol Biol. 2005 ;12(10):855-60.
2004
Alekseyev YO, Hamm ML, Essigmann JM. Aflatoxin B1 formamidopyrimidine adducts are preferentially repaired by the nucleotide excision repair pathway in vivo. Carcinogenesis. 2004 ;25(6):1045-51.
Neeley WL, Delaney JC, Henderson PT, Essigmann JM. In vivo bypass efficiencies and mutational signatures of the guanine oxidation products 2-aminoimidazolone and 5-guanidino-4-nitroimidazole. J Biol Chem. 2004 ;279(42):43568-73.
Delaney JC, Essigmann JM. Mutagenesis, genotoxicity, and repair of 1-methyladenine, 3-alkylcytosines, 1-methylguanine, and 3-methylthymine in alkB Escherichia coli. Proc Natl Acad Sci U S A. 2004 ;101(39):14051-6.
2003
Henderson PT, Delaney JC, Muller JG, Neeley WL, Tannenbaum SR, Burrows CJ, Essigmann JM. The hydantoin lesions formed from oxidation of 7,8-dihydro-8-oxoguanine are potent sources of replication errors in vivo. Biochemistry. 2003 ;42(31):9257-62.