Publications

Found 9 results
Filters: Author is Singh, Vipender  [Clear All Filters]
2022
Fedeles BI, Li D, Singh V. Structural Insights Into Tautomeric Dynamics in Nucleic Acids and in Antiviral Nucleoside Analogs. Front Mol Biosci. 2022 ;8:823253.
2017
Chen F, Bian K, Tang Q, Fedeles BI, Singh V, Humulock ZT, Essigmann JM, Li D. Oncometabolites d- and l-2-Hydroxyglutarate Inhibit the AlkB Family DNA Repair Enzymes under Physiological Conditions. Chem Res Toxicol. 2017 ;30(4):1102-1110.
2015
Fedeles BI, Singh V, Delaney JC, Li D, Essigmann JM. The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond. J Biol Chem. 2015 ;290(34):20734-42.
Fedeles BI, Freudenthal BD, Yau E, Singh V, Chang S-C, Li D, Delaney JC, Wilson SH, Essigmann JM. Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer. Proc Natl Acad Sci U S A. 2015 ;112(33):E4571-80.
Chang S-C, Fedeles BI, Wu J, Delaney JC, Li D, Zhao L, Christov PP, Yau E, Singh V, Jost M, et al. Next-generation sequencing reveals the biological significance of the N(2),3-ethenoguanine lesion in vivo. Nucleic Acids Res. 2015 ;43(11):5489-500.
Singh V, Fedeles BI, Essigmann JM. Role of tautomerism in RNA biochemistry. RNA. 2015 ;21(1):1-13.
2014
Singh V, Peng CSam, Li D, Mitra K, Silvestre KJ, Tokmakoff A, Essigmann JM. Direct Observation of Multiple Tautomers of Oxythiamine and their Recognition by the Thiamine Pyrophosphate Riboswitch. ACS Chem Biol [Internet]. 2014 ;9(1):227-36. Available from: http://pubs.acs.org/doi/abs/10.1021/cb400581f
Singh V, Fedeles BI, Li D, Delaney JC, Kozekov ID, Kozekova A, Marnett LJ, Rizzo CJ, Essigmann JM. Mechanism of Repair of Acrolein- and Malondialdehyde-Derived Exocyclic Guanine Adducts by the α-Ketoglutarate/Fe(II) Dioxygenase AlkB. Chem Res Toxicol. 2014 ;27(9):1619-31.
Li D, Fedeles BI, Singh V, Peng CSam, Silvestre KJ, Simi AK, Simpson JH, Tokmakoff A, Essigmann JM. Tautomerism provides a molecular explanation for the mutagenic properties of the anti-HIV nucleoside 5-aza-5,6-dihydro-2'-deoxycytidine. Proc Natl Acad Sci U S A. 2014 ;111(32):E3252-9.