MIT researchers have now developed a way to determine, by sequencing DNA of liver cells, whether those cells have been exposed to aflatoxin. This profile of mutations could be used to predict whether someone has a high risk of developing liver cancer, potentially many years before tumors...
News
Fri, 08/07/2015
Chronic inflammation caused by disease or exposure to dangerous chemicals has long been linked to cancer, but exactly how this process takes place has remained unclear.
Now, a precise mechanism by which chronic inflammation can lead to cancer has been uncovered by researchers at MIT — a...
Wed, 04/01/2015
In the 1970s, epidemiologists found that workers in factories using vinyl chloride, the key ingredient for PVC plastics, had unusually high rates of a rare form of liver cancer called angiosarcoma.
Biologists later identified a mutation that appears to be associated with this cancer,...
Tue, 07/29/2014
Fifteen years ago, MIT professor John Essigmann and colleagues from the University of Washington had a novel idea for an HIV drug. They thought if they could induce the virus to mutate uncontrollably, they could force it to weaken and eventually die out — a strategy that our immune system uses...
Fri, 07/25/2014
The new manuscript, titled "Tautomerism provides a molecular explanation for the mutagenic properties of the anti-HIV nucleoside 5-aza-5,6-dihydro-2′-deoxycytidine" has been published this week in the early edition of PNAS. The paper studies the mechanism of mutagenesis of the anti-HIV compound...
Mon, 08/19/2013
Essigmann Group submits Journal Article Removal of N-Alkyl Modifications from N2-Alkylguanine and N4-Alkylcytosine in DNA by the Adaptive Response Protein AlkB...
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